Rockefeller University Research Assistant | Laboratory of Molecular Biology in New York, New York
Our research is aimed at the identification of molecular mechanisms that control development and dysfunction of the mammalian cerebellum. We have chosen to study the cerebellum because it is a complex and highly stereotyped structure in which major pattern formation and functional organization occur postnatally. During the past century,classical neuroanatomical studies have very precisely described the complex events that must occur for formation of this brain structure,providing what might be considered as the most detailed information available concerning the development of a given brain region. An extensive literature has documented the importance of cell-cell interactions in the development and maintenance of normal cerebellar architecture,although the mechanisms mediating these interactions remain unknown. Identification of these mechanisms,and analysis of their functions throughout the central nervous system (CNS),are major priorities of the Heintz laboratory.
We are looking for a highly motivated individual to work on a project that will study the molecular basis of selective cellular vulnerability in Huntington's disease. The goal of this project is to identify novel strategies to delay onset and/or slow progression of the disease.
The person who will join our team will be responsible for:
Preparing human brain samples (FFPE or frozen) for chromogenic and fluorescent immunohistochemistry and in situ hybridization
Performing routine stains
Cover slipping slides
The opportunity to learn cutting-edge tissue-clearing techniques for 3D histology as well as an opportunity to learn how to operate a modern light-sheet microscope will be available.
Bachelor's degree required
Experience embedding and sectioning tissue is required as is familiarity with brightfield and confocal microscopes
Familiarity with quantitative tissue analysis software such as Fiji (ImageJ) or HALO Imaging Software is a plus
Candidate must be organized, have good communication skills, and keep clear, accurate records
Rockefeller University does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy, gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service or other non-merit factor. All qualified applicants will receive consideration for employment without regard to the characteristics listed above.
Compensation Range: Min
Compensation Range: Max
Job Locations US-NY-New York
Position Type Regular Full-Time